The pharmaceutical industry is a special field related to people's health and life safety, so production quality and compliance are crucial. In order to meet the strict requirements of Good Manufacturing Practice (GMP) (What is GMP in the pharmaceutical industry?), pharmaceutical companies need to use a variety of different types of production equipment to produce high-quality and safe drugs.
1. General solid equipment
- Pulverizer: used to crush raw drug materials into suitable particle sizes.
- Sifter: used to screen and grade drug particles to ensure consistency.
- Granulator: Makes raw powder into solid particles such as tablets or granules.
- Drying equipment: including ovens and fluidized bed dryers to remove moisture and ensure product stability.
- Tablet press: Presses powder into tablets or compressed granules.
- Capsule filling machine: used to fill powder or granules into capsules.
- Coating equipment: used to coat tablets or granules with an outer layer to improve taste or extend release time.
- Packaging line: including bottling, aluminum-plastic packaging, bag packaging, pillow packaging, boxing, labeling, boxing, code scanning, printing and other equipment for packaging finished products.
2. General liquid preparation equipment
- Liquid preparation equipment: used to mix and dissolve ingredients and auxiliary ingredients.
- Bottle washing machine: used to wash glass bottles to ensure the cleanliness of preparations.
- Blowing filling and sealing machine: put liquid drugs into bottles and seal them.
- Sterilization equipment: ensure the sealing of liquid preparations.
- Boxing, labeling, boxing, code scanning, printing equipment: used for final packaging of liquid preparations
3. Aseptic preparation equipment
- Filtration equipment: used to pass raw material liquid through microporous filter membrane to remove microorganisms and particles.
- Purification equipment: used to purify drugs, usually high performance liquid chromatography (HPLC) or gas chromatograph (GC), etc.
- Sterilization equipment: ensure the sealing of preparations.
- Prefilled filling unit: used for filling and sealing of preparations.
- Freeze drying unit: freeze-drying liquid preparations into powder or solid form.
4. Biological preparation equipment
- Synthesis reaction equipment: used for synthesizing raw materials of biological preparations.
- Fermentation equipment: used for microbial culture and fermentation.
- High-speed centrifuge: used to separate and collect biological preparations.
- Freeze drying unit: freeze-drying biological preparations into powder or solid form.
5. API equipment
- Synthesis reaction equipment: including reaction tower, reactor, pump, tank, etc., used to synthesize API.
- Crystallization equipment: used to crystallize API.
- Filter press: used to separate solid and liquid of API after crystallization.
- Drying equipment: used to remove moisture and ensure the stability of API.
- Vacuum unit: provides vacuum environment for certain process steps.
- Refrigeration unit: used to control reaction temperature.
- Liquid filling equipment: used to fill API into container.
- Solid filling equipment: used to fill powder or granules into container.
6. Chinese medicine preparation equipment
- Extraction equipment: used to extract active ingredients from Chinese herbal medicine.
- Ingredient mixing equipment: mix different Chinese herbal medicine extracts.
- Pill making equipment: make Chinese herbal medicine into pills.
- Spray drying equipment: turn liquid Chinese medicine preparation into powder.
- Vacuum drying equipment: used to prepare dried Chinese medicine products.
7. Auxiliary equipment
- Refrigerator, air compressor, vacuum machine: provide the required cooling, compression and vacuum functions for pharmaceutical equipment.
- Air conditioning purifier: maintain the temperature, humidity and cleanliness level of the clean workshop.
- Dust collector: remove dust and particles generated during the production process.
- Air separation nitrogen generator: provide nitrogen required for the pharmaceutical process.
- Boiler: provide hot water or steam for production.
- Various pipelines, valves, metering and control instruments: used to transport, control and monitor fluids and materials in the production process.
8. Public equipment
- Factory, quality inspection room, animal room, warehouse, cold storage, dangerous goods warehouse: used to store raw materials, finished products and experimental animals, etc.
- Fire pump station: ensure safety and fire prevention.
- Substation: provide electricity.
- Sewage treatment station: treat wastewater.
These are common production equipment in the pharmaceutical industry, and each equipment has a specific role in drug manufacturing. Equipment managers need to have a solid theoretical foundation and rich practical experience to ensure the normal operation of equipment, compliance with product quality, and follow GMP specifications.
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